Sodium-coupled neurotransmitter transporters

A focus is given on the elucidated structures of bacterial and archeal homologues of the neurotransmitter transporters. These structures have provided new insights on the function of real neurotransmitter transporters. Topics being discussed include: the brief history of two neurotransmitter transporter families; the alternating access mechanism; the structure of the bacterial SLC6 homologue LeuT; the binding pocket of the SLC6 neurotransmitter transporters, the NSS transporter "gates" and conformational changes; the properties of SLC1 neurotransmitter transporters; the structure of the archeal SLC1 homologue Glt_Ph; the binding pocket of the eukaryotic glutamate transporters; and finally, glutamate transporter "gates" and conformational changes.