Sol-gel-derived prussian blue-silicate amperometric glucose biosensor

S. Bharathi, O. Lev*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A new type of inorganic biosensor is introduced. The sensor comprises glucose oxidase enzymes encapsulated in a sol-gel-derived Prussian bluesilicate hybrid network. Glucose is detected by the biocatalytic reduction of oxygen followed by catalytic reduction of hydrogen peroxide by the Prussian blue catalyst. The sol-gel silicate entails a rigid encapsulating matrix, the Prussian blue provides chemical catalysis and charge mediation from the reduction site to the supporting electrode, and the enzyme is responsible for the biocatalysis. The feasibility of a dual optical/electrochemical mode of analysis is also demonstrated.

Original languageAmerican English
Pages (from-to)209-216
Number of pages8
JournalApplied Biochemistry and Biotechnology
Issue number2-3
StatePublished - 2000

Bibliographical note

Funding Information:
We wish to thank Prof. S. Sampath for useful collaboration and the Indo-Israel Foundation for financial support.


  • Biosensor
  • Modified electrodes
  • Prussian blue
  • Sol-gel


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