Solid-phase syntheses of constrained RGD scaffolds and their binding to the αvβ3 integrin receptor

Miriam Royo; Wim Van Den Nest; Montserrat Del Fresno; Ariadna Frieden; Dror Yahalom; Michael Rosenblatt; Michael Chorev; Fernando Albericio

doi:10.1016/S0040-4039(01)01510-6

Solid-phase syntheses of constrained RGD scaffolds and their binding to the α_vβ₃ integrin receptor

Miriam Royo^*
, Wim Van Den Nest
, Montserrat Del Fresno
, Ariadna Frieden
, Dror Yahalom
, Michael Rosenblatt
, Michael Chorev
, Fernando Albericio

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We report the solid-phase synthesis of two different families, containing either diketopiperazine or hydantoin structures, of rigidified RGD mimetics and their binding affinity to the α_vβ₃ receptor.

Original language	English
Pages (from-to)	7387-7391
Number of pages	5
Journal	Tetrahedron Letters
Volume	42
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(01)01510-6
State	Published - 15 Oct 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0040-4039(01)01510-6

Cite this

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title = "Solid-phase syntheses of constrained RGD scaffolds and their binding to the αvβ3 integrin receptor",

abstract = "We report the solid-phase synthesis of two different families, containing either diketopiperazine or hydantoin structures, of rigidified RGD mimetics and their binding affinity to the αvβ3 receptor.",

author = "Miriam Royo and \{Van Den Nest\}, Wim and \{Del Fresno\}, Montserrat and Ariadna Frieden and Dror Yahalom and Michael Rosenblatt and Michael Chorev and Fernando Albericio",

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AU - Royo, Miriam

AU - Van Den Nest, Wim

AU - Del Fresno, Montserrat

AU - Frieden, Ariadna

AU - Yahalom, Dror

AU - Rosenblatt, Michael

AU - Chorev, Michael

AU - Albericio, Fernando

PY - 2001/10/15

Y1 - 2001/10/15

N2 - We report the solid-phase synthesis of two different families, containing either diketopiperazine or hydantoin structures, of rigidified RGD mimetics and their binding affinity to the αvβ3 receptor.

AB - We report the solid-phase synthesis of two different families, containing either diketopiperazine or hydantoin structures, of rigidified RGD mimetics and their binding affinity to the αvβ3 receptor.

UR - https://www.scopus.com/pages/publications/0035888142

U2 - 10.1016/S0040-4039(01)01510-6

DO - 10.1016/S0040-4039(01)01510-6

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AN - SCOPUS:0035888142

SN - 0040-4039

VL - 42

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Solid-phase syntheses of constrained RGD scaffolds and their binding to the α_vβ₃ integrin receptor

Abstract

UN SDGs

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