Solid/liquid palladium-catalyzed coupling of haloaryls using alcohols as reducing agents: kinetics and process optimization

Diana Gitis, Sudip Mukhopadhyay, Gadi Rothenberg, Yoel Sasson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Heterogeneous Pd-catalyzed coupling reaction of substituted halobenzenes to biphenyls is performed effectively in different organic solvents using an alcohol as the reducing agent in the presence of a base and a catalytic amount of phase-transfer (PT) agent. The alcohol is oxidized to the respective aldehyde or ketone. Kinetic studies show that the reaction rate equation fits to second order in halobenzene. The effects of reaction temperature, catalyst loading, base concentration, PTC concentration, and alcohol concentration and structure are studied and discussed.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalOrganic Process Research and Development
Volume7
Issue number1
DOIs
StatePublished - Jan 2003

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