Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use

Nissim Garti*, Imad Zakharia, Aviram Spernath, Anan Yaghmur, Abraham Aserin, Roy E. Hoffman, Lewis Jacobs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Winsor IV water-dilutable food-grade microemulsions based on ethoxylated sorbitan esters, water, (R)-(+)-limonene, ethanol, and propylene glycol have been prepared. Tocopherols and lycopene, two active lipophilic antioxidants, have been solubilized in the water-in-oil, bicontinuous, and oil-in-water microemulsions several times more than the oil (R)-(+)-limonene dissolution capacity. Dilution of the aqueous phase and decrease of the surfactant content strongly affect the solubilization capacity and solubilization efficiency of the microemulsion. Self-diffusion coefficients of the water and the oil in the presence of the solubilizates were correlated to the solubilization capacity, and are indicative of the locus of solubilization of the lycopene in the different microstructures.

Original languageEnglish
Pages (from-to)184-189
Number of pages6
JournalProgress in Colloid and Polymer Science
Volume126
DOIs
StatePublished - 2004

Keywords

  • Food microemulsion
  • Lycopene
  • Self-diffusion NMR
  • Solubilization capacity
  • Tocopherols
  • Vitamin E

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