Solvation of large molecules: Some exact results on the dependence on volume and surface area of the solute

A. Ben-Naim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The solvation Gibbs and Helmholtz energies are evaluated exactly in two model systems. One is a modification of an interstitial model for water, the second is a non ideal gas mixture within the second virial approximation. In both systems the general form of the solvation Gibbs energy of a large solute s is ΔGs* = aV s + bAs where Vs and As are the volume and surface area of the solute s. We also show that this general form is likely to hold true in any real solution.

Original languageEnglish
Pages (from-to)203-216
Number of pages14
JournalBiophysical Chemistry
Volume51
Issue number2-3
DOIs
StatePublished - Aug 1994

Keywords

  • Gibbs and Helmholtz energies
  • Large molecules
  • Solvation

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