Some taste substances are direct activators of G-proteins

M. Naim*, R. Seifert, B. Nurnberg, L. Grunbaum, G. Schultz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and G(i)/G(o)-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.

Original languageEnglish
Pages (from-to)451-454
Number of pages4
JournalBiochemical Journal
Volume297
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

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