Abstract
Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and G(i)/G(o)-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.
Original language | English |
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Pages (from-to) | 451-454 |
Number of pages | 4 |
Journal | Biochemical Journal |
Volume | 297 |
Issue number | 3 |
DOIs | |
State | Published - 1994 |
Externally published | Yes |