TY - JOUR
T1 - Soy-derived isoflavones treatment in children with hypercholesterolemia
T2 - A pilot study
AU - Zung, Amnon
AU - Shachar, Sabina
AU - Zadik, Zvi
AU - Kerem, Zohar
PY - 2010
Y1 - 2010
N2 - Aims: To evaluate for the first time in children the effect of soy-derived isoflavones on lipid profile and insulin resistance. Methods: Twelve hypercholesterolemic children (8 females) aged 5.3 to 11.2 years have completed a prospective, controlled pilot study. After a low-fat diet for 12 weeks, children who maintained high cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels were randomly assigned to three intervention periods of either placebo or low and high dose isoflavone (16 or 48 mg) consumption, each period lasting 8 weeks. Results: The diet significantly reduced LDL-C and apolipoprotein B (Apo B) levels. However, isoflavones had no effect on cholesterol, LDLC, high-density lipoprotein-cholesterol (HDLC), triglycerides, lipoprotein (a), Apo B, or insulin resistance, at either low or high doses. Isoflavones had no effect on sex hormones, gonadotropins, sex-hormone binding globulin and thyroid hormones. Conclusions: The results of this pilot study do ' not suggest a beneficial role of an isoflavoneenriched diet in children with hypercholesterolemia.
AB - Aims: To evaluate for the first time in children the effect of soy-derived isoflavones on lipid profile and insulin resistance. Methods: Twelve hypercholesterolemic children (8 females) aged 5.3 to 11.2 years have completed a prospective, controlled pilot study. After a low-fat diet for 12 weeks, children who maintained high cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels were randomly assigned to three intervention periods of either placebo or low and high dose isoflavone (16 or 48 mg) consumption, each period lasting 8 weeks. Results: The diet significantly reduced LDL-C and apolipoprotein B (Apo B) levels. However, isoflavones had no effect on cholesterol, LDLC, high-density lipoprotein-cholesterol (HDLC), triglycerides, lipoprotein (a), Apo B, or insulin resistance, at either low or high doses. Isoflavones had no effect on sex hormones, gonadotropins, sex-hormone binding globulin and thyroid hormones. Conclusions: The results of this pilot study do ' not suggest a beneficial role of an isoflavoneenriched diet in children with hypercholesterolemia.
KW - Children
KW - Hypercholesterolemia
KW - Isoflavones
KW - Soy
UR - http://www.scopus.com/inward/record.url?scp=77950839883&partnerID=8YFLogxK
U2 - 10.1515/JPEM.2010.23.1-2.133
DO - 10.1515/JPEM.2010.23.1-2.133
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AN - SCOPUS:77950839883
SN - 0334-018X
VL - 23
SP - 133
EP - 141
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 1-2
ER -