SP1 protein-based nanostructures and arrays

Izhar Medalsy, Or Dgany, Mukhles Sowwan, Hezy Cohen, Alevtyna Yukashevska, Sharon G. Wolf, Amnon Wolf, Abraham Koster, Orna Almog, Ira Marton, Yehonathan Pouny, Arie Altman, Oded Shoseyov*, Danny Porath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Controlled formation of complex nanostructures is one of the main goals of nanoscience and nanotechnology. Stable Protein 1 (SP1) is a boiling-stable ring protein complex, 11 nm in diameter, which self-assembles from 12 identical monomers. SP1 can be utilized to form large ordered arrays; it can be easily modified by genetic engineering to produce various mutants; it is also capable of binding gold nanoparticles (GNPs) and thus forming protein-GNP chains made of alternating SP1s and GNPs. We report the formation and the protocols leading to the formation of those nanostructures and their characterization by transmission electron microscopy, atomic force microscopy, and electrostatic force microscopy. Further control over the GNP interdistances within the protein-GNP chains may lead to the formation of nanowires and structures that may be useful for nanoelectronics.

Original languageAmerican English
Pages (from-to)473-477
Number of pages5
JournalNano Letters
Issue number2
StatePublished - Feb 2008


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