Specific attachment of T-lymphocytes from cancer patients to tumor cells

Uri Galili; Marco Caine; Ciro Servadio; Michael Schlesinger

doi:10.1016/S0304-3835(77)94882-0

Specific attachment of T-lymphocytes from cancer patients to tumor cells

Uri Galili^*, Marco Caine, Ciro Servadio, Michael Schlesinger

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The present study describes a new approach for detecting the immune reaction of peripheral blood lymphocytes of cancer patients against tumor antigens. T-lymphocytes from patients with carcinoma of the urinary bladder were found to attach specifically to monolayers of cells of a urinary bladder carcinoma line (T₂₄). The attached T-cells were identified by their capacity to form E-rosettes with sheep red blood cells. The number of rosette forming-target attached lymphocytes (RF-TAL) was 6 times higher in bladder carcinoma patients than in healthy controls or in patients bearing other types of cancer.

Original language	English
Pages (from-to)	121-124
Number of pages	4
Journal	Cancer Letters
Volume	3
Issue number	C
DOIs	https://doi.org/10.1016/S0304-3835(77)94882-0
State	Published - 1977

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10.1016/S0304-3835(77)94882-0

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abstract = "The present study describes a new approach for detecting the immune reaction of peripheral blood lymphocytes of cancer patients against tumor antigens. T-lymphocytes from patients with carcinoma of the urinary bladder were found to attach specifically to monolayers of cells of a urinary bladder carcinoma line (T24). The attached T-cells were identified by their capacity to form E-rosettes with sheep red blood cells. The number of rosette forming-target attached lymphocytes (RF-TAL) was 6 times higher in bladder carcinoma patients than in healthy controls or in patients bearing other types of cancer.",

author = "Uri Galili and Marco Caine and Ciro Servadio and Michael Schlesinger",

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doi = "10.1016/S0304-3835(77)94882-0",

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AU - Galili, Uri

AU - Caine, Marco

AU - Servadio, Ciro

AU - Schlesinger, Michael

PY - 1977

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N2 - The present study describes a new approach for detecting the immune reaction of peripheral blood lymphocytes of cancer patients against tumor antigens. T-lymphocytes from patients with carcinoma of the urinary bladder were found to attach specifically to monolayers of cells of a urinary bladder carcinoma line (T24). The attached T-cells were identified by their capacity to form E-rosettes with sheep red blood cells. The number of rosette forming-target attached lymphocytes (RF-TAL) was 6 times higher in bladder carcinoma patients than in healthy controls or in patients bearing other types of cancer.

AB - The present study describes a new approach for detecting the immune reaction of peripheral blood lymphocytes of cancer patients against tumor antigens. T-lymphocytes from patients with carcinoma of the urinary bladder were found to attach specifically to monolayers of cells of a urinary bladder carcinoma line (T24). The attached T-cells were identified by their capacity to form E-rosettes with sheep red blood cells. The number of rosette forming-target attached lymphocytes (RF-TAL) was 6 times higher in bladder carcinoma patients than in healthy controls or in patients bearing other types of cancer.

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JO - Cancer Letters

JF - Cancer Letters

IS - C

ER -

Specific attachment of T-lymphocytes from cancer patients to tumor cells

Abstract

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