Specific eradication of HIV-1 from infected cultured cells

Aviad Levin; Zvi Hayouka; Assaf Friedler; Abraham Loyter

doi:10.1186/1742-6405-7-31

Specific eradication of HIV-1 from infected cultured cells

Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.

Original language	English
Article number	31
Journal	AIDS Research and Therapy
Volume	7
DOIs	https://doi.org/10.1186/1742-6405-7-31
State	Published - 19 Aug 2010

Bibliographical note

Funding Information:
This work was supported by the Israeli Science Foundation (A. Loyter) and by a starting grant from the European Research Council (ERC) (to AF). Cells and WT HIV-1 virus were provided by the NIH Reagent Program, Division of AIDS, NIAID, NIH (Bethesda, MD, USA).

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10.1186/1742-6405-7-31

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AU - Hayouka, Zvi

AU - Friedler, Assaf

AU - Loyter, Abraham

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AB - A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.

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Specific eradication of HIV-1 from infected cultured cells

Abstract

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