Specific Increase in Polyamine Levels in Chick Embryo Cells Transformed by Rous Sarcoma Virus

Shraga Don, Haviva Wiener, Uriel Bachrach

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Chick embryo fibroblasts and chorioallantoic membranes of chick embryos infected with oncogenic or nononcogenic viruses were analyzed for polyamines. Nononcogenic viruses (influenze, Newcastle disease, or vaccinia virus) had no effect on the polyamine content of chorioallantoic membranes. Transformation of chorioallantoic membranes by a wild-type or temperature-sensitive mutant strain of Rous sarcoma virus under permissive conditions (37°) caused a 2- to 4-fold increase in cellular spermidine and putrescine content. Only putrescine accumulated in chick embryo fibroblasts transformed by Rous sarcoma virus at 37°. At the nonpermissive temperature (42°), the temperature-sensitive mutant, unlike the wild-type strain, did not alter cellular morphology or polyamine content.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalCancer Research
Volume35
Issue number1
StatePublished - Jan 1975

Fingerprint

Dive into the research topics of 'Specific Increase in Polyamine Levels in Chick Embryo Cells Transformed by Rous Sarcoma Virus'. Together they form a unique fingerprint.

Cite this