TY - JOUR
T1 - Specificity of Ca2+ and Mg2+ binding to phosphatidylserine vesicles and resultant phase changes of bilayer membrane structure
AU - Newton, Carolyn
AU - Pangborn, Walter
AU - Nir, Shlomo
AU - Papahadjopoulos, Demetrios
PY - 1978/1/19
Y1 - 1978/1/19
N2 - Differences in the interaction of Ca2+ and Mg2+ with phosphatidylserine vesicles were revealed by binding studies, differential scanning calorimetry and X-ray diffraction. The two cations produced structurally different complexes with phosphatidylserine as evidenced by phase transition characteristics, lamellar spacings, and hydrocarbon packing. Ca2+ effectively competes with Mg2+ for phosphatidylserine binding sites. Analysis of the binding data showed that Ca2+ had a ten-fold greater intrinsic binding constant for phosphatidylserine.
AB - Differences in the interaction of Ca2+ and Mg2+ with phosphatidylserine vesicles were revealed by binding studies, differential scanning calorimetry and X-ray diffraction. The two cations produced structurally different complexes with phosphatidylserine as evidenced by phase transition characteristics, lamellar spacings, and hydrocarbon packing. Ca2+ effectively competes with Mg2+ for phosphatidylserine binding sites. Analysis of the binding data showed that Ca2+ had a ten-fold greater intrinsic binding constant for phosphatidylserine.
UR - http://www.scopus.com/inward/record.url?scp=0018272505&partnerID=8YFLogxK
U2 - 10.1016/0005-2736(78)90398-X
DO - 10.1016/0005-2736(78)90398-X
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C2 - 620034
AN - SCOPUS:0018272505
SN - 0005-2736
VL - 506
SP - 281
EP - 287
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
IS - 2
ER -