TY - JOUR
T1 - Spontaneous and enzyme-induced dimer formation and its role in membrane permeability I. The permeability of non-electrolytes at high concentration
AU - Stein, W. D.
PY - 1962/5/7
Y1 - 1962/5/7
N2 - The glycols ethylene glycol, diethylene glycol, 1,2-dihydroxypropane and 1,3-dihydroxypropane have been presumed to cross the membrane of the red blood cell by simple diffusion. It is shown, however, that the theory for penetration by simple diffusion fails at the higher concentrations of glycol. The experimental results can be accounted for by the assumption that interactions occur at these high concentrations between glycol molecules in the main bulk of the permeant solution. These interactions lead to the formation of hydrogen-bonded dimers and oligomers which can penetrate the membrane at a rate which differs from the rate for the monomers. Data on the rate of penetration from mixtures of glycols and studies on glycerol, trihydroxybutanol and thiourea penetration support this view.
AB - The glycols ethylene glycol, diethylene glycol, 1,2-dihydroxypropane and 1,3-dihydroxypropane have been presumed to cross the membrane of the red blood cell by simple diffusion. It is shown, however, that the theory for penetration by simple diffusion fails at the higher concentrations of glycol. The experimental results can be accounted for by the assumption that interactions occur at these high concentrations between glycol molecules in the main bulk of the permeant solution. These interactions lead to the formation of hydrogen-bonded dimers and oligomers which can penetrate the membrane at a rate which differs from the rate for the monomers. Data on the rate of penetration from mixtures of glycols and studies on glycerol, trihydroxybutanol and thiourea penetration support this view.
UR - http://www.scopus.com/inward/record.url?scp=50549175008&partnerID=8YFLogxK
U2 - 10.1016/0006-3002(62)90696-0
DO - 10.1016/0006-3002(62)90696-0
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C2 - 13916651
AN - SCOPUS:50549175008
SN - 0006-3002
VL - 59
SP - 35
EP - 46
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
IS - 1
ER -