Spontaneous and evoked activity patterns diverge over development

Lilach Avitan, Zac Pujic, Jan Mölter, Shuyu Zhu, Biao Sun, Geoffrey J. Goodhill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The immature brain is highly spontaneously active. Over development this activity must be integrated with emerging patterns of stimulus-evoked activity, but little is known about how this occurs. Here we investigated this question by recording spontaneous and evoked neural activity in the larval zebrafish tectum from 4 to 15 days post-fertilisation. Correlations within spontaneous and evoked activity epochs were comparable over development, and their neural assemblies refined in similar ways. However, both the similarity between evoked and spontaneous assemblies, and also the geometric distance between spontaneous and evoked patterns, decreased over development. At all stages of development, evoked activity was of higher dimension than spontaneous activity. Thus, spontaneous and evoked activity do not converge over development in this system, and these results do not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.

Original languageAmerican English
Article numbere61942
StatePublished - 2021

Bibliographical note

Funding Information:
Imaging was performed at the Queensland Brain Institute’s Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078.

Publisher Copyright:
© Avitan et al.


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