TY - JOUR
T1 - Stability and removal of spironolactone from wastewater
AU - Sulaiman, Saleh
AU - Khamis, Mustafa
AU - Nir, Shlomo
AU - Lelario, Filomena
AU - Scrano, Laura
AU - Bufo, Sabino A.
AU - Karaman, Rafik
N1 - Publisher Copyright:
Copyright © 2015 Taylor & Francis Group, LLC.
PY - 2015/9/19
Y1 - 2015/9/19
N2 - Stability and removal of spironolactone (SP) from wastewater produced at Al-Quds University Campus were investigated. Kinetic studies on both pure water and wastewater coming from secondary treatment (activated sludge) demonstrated that the potassium-sparing diuretic (water pill), spironolactone, underwent degradation to its hydrolytic derivative, canrenone, in both media. The first-order hydrolysis rate of SP in activated sludge at 25°C (3.80 × 10-5 s-1) was about 49-fold larger than in pure water (7.4 × 10-7 s-1). The overall performance of the wastewater treatment plant (WWTP) installed in the University Campus was assessed showing that more than 90% of spiked SP was removed together with its newly identified metabolites. In order to look for a technology to supplement or replace ultra-filtration membranes, the effectiveness of adsorption and filtration by micelle-clay filters for removing SP was tested in comparison with activated charcoal. Batch adsorption in aqueous suspensions was well described by Langmuir isotherms, showing a better removal by the micelle-clay material. Filtration of SP water solutions by columns filled with a mixture of sand and a micelle-clay complex showed complete removal of the drug at concentrations higher than in sand/activated-charcoal filled filters.
AB - Stability and removal of spironolactone (SP) from wastewater produced at Al-Quds University Campus were investigated. Kinetic studies on both pure water and wastewater coming from secondary treatment (activated sludge) demonstrated that the potassium-sparing diuretic (water pill), spironolactone, underwent degradation to its hydrolytic derivative, canrenone, in both media. The first-order hydrolysis rate of SP in activated sludge at 25°C (3.80 × 10-5 s-1) was about 49-fold larger than in pure water (7.4 × 10-7 s-1). The overall performance of the wastewater treatment plant (WWTP) installed in the University Campus was assessed showing that more than 90% of spiked SP was removed together with its newly identified metabolites. In order to look for a technology to supplement or replace ultra-filtration membranes, the effectiveness of adsorption and filtration by micelle-clay filters for removing SP was tested in comparison with activated charcoal. Batch adsorption in aqueous suspensions was well described by Langmuir isotherms, showing a better removal by the micelle-clay material. Filtration of SP water solutions by columns filled with a mixture of sand and a micelle-clay complex showed complete removal of the drug at concentrations higher than in sand/activated-charcoal filled filters.
KW - Activated carbon
KW - micelle-clay complex
KW - spironolactone
KW - stability in sludge
KW - wastewater treatment
UR - http://www.scopus.com/inward/record.url?scp=84937796677&partnerID=8YFLogxK
U2 - 10.1080/10934529.2015.1047668
DO - 10.1080/10934529.2015.1047668
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C2 - 26191987
AN - SCOPUS:84937796677
SN - 1093-4529
VL - 50
SP - 1127
EP - 1135
JO - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
JF - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
IS - 11
ER -
