Stability of diltiazem in different biological fluids

Angus M. McLean, Eugenio A. Cefali, Jennifer S. Roden, Mario A. Gonzalez*, Meir Bialer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half‐life of 27h), followed by plasma (half‐life of 88h), while the least significant degradation rate was observed in gastric fluid (half‐life 153h). The kinetic profiles of diltiazem hydrolysis indicate that hydrolytic degradation in the biological fluids makes a minimal contribution to the clearance and disposition of the drug.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalBiopharmaceutics and Drug Disposition
Volume12
Issue number5
DOIs
StatePublished - Jul 1991

Keywords

  • Diltiazem
  • Stability

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