Stability of salicylamide‐caffeine complex at different temperatures and its thermodynamic parameters

M. Donbrow; E. Touitou; H. Ben Shalom

doi:10.1111/j.2042-7158.1976.tb04044.x

Stability of salicylamide‐caffeine complex at different temperatures and its thermodynamic parameters

M. Donbrow^*, E. Touitou, H. Ben Shalom

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45°, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25° an additional phase was formed which was found to be an insoluble 1: 1 complex. The enthalpies and entropies of interactions were evaluated. They indicate that the interaction is exothermic and enthalpy controlled.

Original language	English
Pages (from-to)	766-769
Number of pages	4
Journal	Journal of Pharmacy and Pharmacology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1111/j.2042-7158.1976.tb04044.x
State	Published - Oct 1976

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abstract = "The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45°, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25° an additional phase was formed which was found to be an insoluble 1: 1 complex. The enthalpies and entropies of interactions were evaluated. They indicate that the interaction is exothermic and enthalpy controlled.",

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N2 - The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45°, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25° an additional phase was formed which was found to be an insoluble 1: 1 complex. The enthalpies and entropies of interactions were evaluated. They indicate that the interaction is exothermic and enthalpy controlled.

AB - The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45°, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25° an additional phase was formed which was found to be an insoluble 1: 1 complex. The enthalpies and entropies of interactions were evaluated. They indicate that the interaction is exothermic and enthalpy controlled.

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Stability of salicylamide‐caffeine complex at different temperatures and its thermodynamic parameters

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