Stable RNA synthesis and its control in mycoplasma capricolum

Gad Glaser*, Aharon Razin, Shmuel Razin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The synthesis of stable RNA in Mycoplasma capricolum was studied by [32P] labelin g of cellular RNA of cells grown in a partially-defined medium in the presence or absence of an amino acid mixture supplement. The results indicate that M. capricolum employs the same stringent control mechanism used by E. coli cells, as judged by a decreased synthesis of stable RNA and accumulation of 5′-triphosphoguanosine-3′-diphosphate (pppGpp) and 5′-diphosphoguanosine-3′-diphosphate (ppGpp) in response to amino acid starvation. In addition, the results suggest that precursors of stable RNA accumulate and an intracellular pool of the precursors exists at all times under the growth conditions used by us. These findings may be interpreted to reflect a slow rate of RNA processing in M. capricolum.

Original languageEnglish
Pages (from-to)3641-3646
Number of pages6
JournalNucleic Acids Research
Volume9
Issue number15
DOIs
StatePublished - 11 Aug 1981

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