State-dependence of climbing fiber-driven calcium transients in Purkinje cells

D. Rokni*, Y. Yarom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The recently described bi-stability of Purkinje cells and the state-dependence of the complex spike waveform suggest that calcium currents may play a pivotal role in both the complex spike waveform and the state of the membrane voltage. Here we used Ca2+ imaging to record the changes in intracellular [Ca2+] that are elicited by either spontaneous or climbing fiber-evoked activity in rat Purkinje cells. We show that a continuous somatic Ca2+ influx occurs during an "UP" state. Furthermore Ca2+ transients that are evoked by climbing fiber stimulation are state-dependent. Somatic transients are smaller following an "UP" state, while dendritic transients are smaller following a "DOWN" state. The state-dependence of these signals should affect the intrinsic firing of Purkinje cells as well as plastic processes that modulate synaptic strength.

Original languageAmerican English
Pages (from-to)694-701
Number of pages8
JournalNeuroscience
Volume162
Issue number3
DOIs
StatePublished - 1 Sep 2009

Keywords

  • bi-stability
  • complex spike
  • simple spike

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