Statistical design of the child and adolescent trial for cardiovascular health (catch): Implications of cluster randomization

David M. Zucker; Edward Lakatos; Larry S. Webber; David M. Murray; Sonja M. McKinlay; Henry A. Feldman; Steve H. Kelder; Philip R. Nader

doi:10.1016/0197-2456(94)00026-Y

Statistical design of the child and adolescent trial for cardiovascular health (catch): Implications of cluster randomization

David M. Zucker, Edward Lakatos, Larry S. Webber, David M. Murray, Sonja M. McKinlay^*, Henry A. Feldman, Steve H. Kelder, Philip R. Nader

^*Corresponding author for this work

Department of Statistics

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

This paper describes some statistical considerations for the Child and Adolescent Trial for Cardiovascular Health (CATCH), a large-scale community health trial sponsored by the National Heart, Lung, and Blood Institute. The trial involves randomization of entire schools rather than individual students to the experimental arms. The paper discussed the implications of this form of randomization for the design and analysis of the trial. The power calculations and analysis plan for the trial are presented in detail. The handling of outmigrating and inmigrating students is also discussed.

Original language	English
Pages (from-to)	96-118
Number of pages	23
Journal	Controlled Clinical Trials
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0197-2456(94)00026-Y
State	Published - Apr 1995

Keywords

Cluster randomization
community studies
group randomization
intention-to-treat principle
multilevel modeling

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10.1016/0197-2456(94)00026-Y

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title = "Statistical design of the child and adolescent trial for cardiovascular health (catch): Implications of cluster randomization",

abstract = "This paper describes some statistical considerations for the Child and Adolescent Trial for Cardiovascular Health (CATCH), a large-scale community health trial sponsored by the National Heart, Lung, and Blood Institute. The trial involves randomization of entire schools rather than individual students to the experimental arms. The paper discussed the implications of this form of randomization for the design and analysis of the trial. The power calculations and analysis plan for the trial are presented in detail. The handling of outmigrating and inmigrating students is also discussed.",

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AU - McKinlay, Sonja M.

AU - Feldman, Henry A.

AU - Kelder, Steve H.

AU - Nader, Philip R.

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AB - This paper describes some statistical considerations for the Child and Adolescent Trial for Cardiovascular Health (CATCH), a large-scale community health trial sponsored by the National Heart, Lung, and Blood Institute. The trial involves randomization of entire schools rather than individual students to the experimental arms. The paper discussed the implications of this form of randomization for the design and analysis of the trial. The power calculations and analysis plan for the trial are presented in detail. The handling of outmigrating and inmigrating students is also discussed.

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Statistical design of the child and adolescent trial for cardiovascular health (catch): Implications of cluster randomization

Abstract

Keywords

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