Statistical design of the child and adolescent trial for cardiovascular health (catch): Implications of cluster randomization

David M. Zucker, Edward Lakatos, Larry S. Webber, David M. Murray, Sonja M. McKinlay*, Henry A. Feldman, Steve H. Kelder, Philip R. Nader

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

This paper describes some statistical considerations for the Child and Adolescent Trial for Cardiovascular Health (CATCH), a large-scale community health trial sponsored by the National Heart, Lung, and Blood Institute. The trial involves randomization of entire schools rather than individual students to the experimental arms. The paper discussed the implications of this form of randomization for the design and analysis of the trial. The power calculations and analysis plan for the trial are presented in detail. The handling of outmigrating and inmigrating students is also discussed.

Original languageAmerican English
Pages (from-to)96-118
Number of pages23
JournalControlled Clinical Trials
Volume16
Issue number2
DOIs
StatePublished - Apr 1995

Keywords

  • Cluster randomization
  • community studies
  • group randomization
  • intention-to-treat principle
  • multilevel modeling

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