Stem cell-based therapy for prevention of delayed fracture union: A randomized and prospective preliminary study

Meir Liebergall; Josh Schroeder; Rami Mosheiff; Zulma Gazit; Zilberman Yoram; Linda Rasooly; Anat Daskal; Amal Khoury; Yoram Weil; Shaul Beyth

doi:10.1038/mt.2013.109

Stem cell-based therapy for prevention of delayed fracture union: A randomized and prospective preliminary study

Meir Liebergall^*, Josh Schroeder, Rami Mosheiff, Zulma Gazit, Zilberman Yoram, Linda Rasooly, Anat Daskal, Amal Khoury, Yoram Weil, Shaul Beyth

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy of early minimally invasive intervention (MII) in the treatment of these fractures. A total 24 consecutive patients who underwent operative treatment for distal tibial fractures were randomized into a control and an intervention group. MII entailed aspirating iliac crest bone marrow and peripheral blood, yielding mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) respectively, that were mixed with demineralized bone matrix (DBM) and injected under fluoroscopic control into the fracture site. No complications occurred in either group. The median time to union was 1.5 months in the MII group and 3 months in the control group. MII was found to be a safe and efficient procedure.

Original language	English
Pages (from-to)	1631-1638
Number of pages	8
Journal	Molecular Therapy
Volume	21
Issue number	8
DOIs	https://doi.org/10.1038/mt.2013.109
State	Published - Aug 2013
Externally published	Yes

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10.1038/mt.2013.109

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abstract = "Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy of early minimally invasive intervention (MII) in the treatment of these fractures. A total 24 consecutive patients who underwent operative treatment for distal tibial fractures were randomized into a control and an intervention group. MII entailed aspirating iliac crest bone marrow and peripheral blood, yielding mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) respectively, that were mixed with demineralized bone matrix (DBM) and injected under fluoroscopic control into the fracture site. No complications occurred in either group. The median time to union was 1.5 months in the MII group and 3 months in the control group. MII was found to be a safe and efficient procedure.",

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AU - Liebergall, Meir

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AU - Mosheiff, Rami

AU - Gazit, Zulma

AU - Yoram, Zilberman

AU - Rasooly, Linda

AU - Daskal, Anat

AU - Khoury, Amal

AU - Weil, Yoram

AU - Beyth, Shaul

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AB - Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy of early minimally invasive intervention (MII) in the treatment of these fractures. A total 24 consecutive patients who underwent operative treatment for distal tibial fractures were randomized into a control and an intervention group. MII entailed aspirating iliac crest bone marrow and peripheral blood, yielding mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) respectively, that were mixed with demineralized bone matrix (DBM) and injected under fluoroscopic control into the fracture site. No complications occurred in either group. The median time to union was 1.5 months in the MII group and 3 months in the control group. MII was found to be a safe and efficient procedure.

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Stem cell-based therapy for prevention of delayed fracture union: A randomized and prospective preliminary study

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