Stereocomplexes, based on biodegradable polymers and bioactive macromolecules

Joram Slager; Micha Gladnikoff; Abraham J. Domb

doi:10.1002/1521-3900(200110)175:1<105::AID-MASY105>3.0.CO;2-C

Stereocomplexes, based on biodegradable polymers and bioactive macromolecules

Joram Slager^*
, Micha Gladnikoff
, Abraham J. Domb

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH

Original language	English
Pages (from-to)	105-116
Number of pages	12
Journal	Macromolecular Symposia
Volume	175
DOIs	https://doi.org/10.1002/1521-3900(200110)175:1<105::AID-MASY105>3.0.CO;2-C
State	Published - 2001

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title = "Stereocomplexes, based on biodegradable polymers and bioactive macromolecules",

abstract = "Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5\% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH",

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AU - Domb, Abraham J.

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N2 - Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH

AB - Stereocomplexation between two enantiomeric polymers such as D-PLA and L-PLA have been described in the literature. No reports up till now have been published on the complexation between two non-identical complementary polymers. Stereocomplexes between poly(lactide) enantiomers and a representative peptide, LHRH, was investigated. The complex was shown to be of physical character (NMR, IR, X-ray) without any irriversibility. DSC-scans show an additional signal related to the second (β-) and thermally less stable form of isotactic PLA. A linear correlation was found between the amount of peptide added to D-PLA and the measured enthalpies. An overall decrease in crystallinity was noticed. Less than 5% of the total amount of peptide was found free in solution after complexation with PLA. A controlled release of peptide was measured for about 3 months in-vitro. In-vivo similar results were obtained as earlier reported for a commercial available controlled release device containing LHRH

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Stereocomplexes, based on biodegradable polymers and bioactive macromolecules

Abstract

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