Stereospecific oxidation by Compound I of Cytochrome P450 does not proceed in a concerted synchronous manner

Sam P. de Visser; François Ogliaro; Sason Shaik

doi:10.1039/b105571m

Stereospecific oxidation by Compound I of Cytochrome P450 does not proceed in a concerted synchronous manner

Sam P. de Visser
, François Ogliaro
, Sason Shaik^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Calculations show that the transition structure for the synchronous oxygen transfer by Compound I is a second order saddle point. The process is unlikely.

Original language	English
Pages (from-to)	2322-2323
Number of pages	2
Journal	Chemical Communications
Volume	1
Issue number	22
DOIs	https://doi.org/10.1039/b105571m
State	Published - 2001

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title = "Stereospecific oxidation by Compound I of Cytochrome P450 does not proceed in a concerted synchronous manner",

abstract = "Calculations show that the transition structure for the synchronous oxygen transfer by Compound I is a second order saddle point. The process is unlikely.",

author = "\{de Visser\}, \{Sam P.\} and Fran{\c c}ois Ogliaro and Sason Shaik",

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N2 - Calculations show that the transition structure for the synchronous oxygen transfer by Compound I is a second order saddle point. The process is unlikely.

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Stereospecific oxidation by Compound I of Cytochrome P450 does not proceed in a concerted synchronous manner

Abstract

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