Steroidal Nanodrugs Based on Pegylated Nanoliposomes Remote Loaded with Amphipathic Weak Acids Steroid Prodrugs as Anti-Inflammatory Agents: Innovation and Production

Keren Turjeman, Yechezkel Barenholz

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Inflammation is a vital physiological response for the survival of the organism. The inflammatory process is composed of three phases: acute inflammation, immune response, and chronic inflammation. Glucocorticosteroids (GCs) are widely used, highly efficacious anti-inflammatory drugs. This chapter presents strategies for the treatment of inflammation using nanotechnology include, targeting macrophages and targeting proinflammatory molecules. It discusses nanosterically stabilized liposomes (NSSL) for the treatment of diseases with an inflammatory component. Passive loading is defined as a loading of drug/agent during liposome preparation. For a stable encapsulation of drugs by the passive loading method, only highly hydrophobic or highly hydrophilic drugs can be used. The chapter investigates the therapeutic efficacy of GC nanodrug in several murine models for disease with an inflammatory component. Treatment with NSSL MPS reduced inflammation and demyelination in brains and spinal cords of mice with AT-EAE compared with free MPS-treated mice and control mice.
Original languageAmerican English
Title of host publicationPharmaceutical Nanotechnology
Subtitle of host publication Innovation and Production
EditorsJean Cornier , Andrew Owen, Arno Kwade, Marcel Van de Voorde
Place of PublicationWeinheim, Germany
PublisherWiley - VCH Verlag GmbH & CO. KGaA
Pages603-632
Number of pages30
ISBN (Electronic)9783527800681
ISBN (Print)9783527340545
DOIs
StatePublished - 2 Dec 2016

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