TY - JOUR
T1 - Steroids and follicular rupture at ovulation
AU - Tsafriri, A.
AU - Abisogun, A. O.
AU - Reich, R.
PY - 1987
Y1 - 1987
N2 - The preovulatory surge of gonadotropins stimulates follocular steroidogenesis and changes from estrogen as the major product to progesterone. We shall overview the studies dealing with the role of ovarian steroidogenesis in follicular rupture at ovulation. Several inhibitors of steroidogenesis blocked follicular rupture in vivo. Likewise, RU 38486 partially blocked ovulation triggered by hCG. Collectively, these data support the knowledge that follicular steroidogenesis is required for ovulation. Recent studies confirmed the essential role of plasminogen activator (PA) in follicular rupture. The LH stimulation of PA activity was partially blocked by several inhibitors of steroidogenesis and it could be restored by the addition of progesterone, testosterone and estradiol-17β, but not the non-aromatizable 5α-dihydrotestosterone. Gonadotropic stimulation enhanced only the synthesis of tissue type PA (t-PA) and not that of urokinase. Likewise, inhibition of steroidogenesis, reduced only the synthesis of t-PA and was reversed by addition of estradiol-17β. It seems, therefore, that follicular steroids, most probably estrogen, are involved in the preovulatory rise in follicular t-PA activity.
AB - The preovulatory surge of gonadotropins stimulates follocular steroidogenesis and changes from estrogen as the major product to progesterone. We shall overview the studies dealing with the role of ovarian steroidogenesis in follicular rupture at ovulation. Several inhibitors of steroidogenesis blocked follicular rupture in vivo. Likewise, RU 38486 partially blocked ovulation triggered by hCG. Collectively, these data support the knowledge that follicular steroidogenesis is required for ovulation. Recent studies confirmed the essential role of plasminogen activator (PA) in follicular rupture. The LH stimulation of PA activity was partially blocked by several inhibitors of steroidogenesis and it could be restored by the addition of progesterone, testosterone and estradiol-17β, but not the non-aromatizable 5α-dihydrotestosterone. Gonadotropic stimulation enhanced only the synthesis of tissue type PA (t-PA) and not that of urokinase. Likewise, inhibition of steroidogenesis, reduced only the synthesis of t-PA and was reversed by addition of estradiol-17β. It seems, therefore, that follicular steroids, most probably estrogen, are involved in the preovulatory rise in follicular t-PA activity.
UR - http://www.scopus.com/inward/record.url?scp=0023577690&partnerID=8YFLogxK
U2 - 10.1016/0022-4731(87)90328-1
DO - 10.1016/0022-4731(87)90328-1
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C2 - 2961934
AN - SCOPUS:0023577690
SN - 0022-4731
VL - 27
SP - 359
EP - 363
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
IS - 1-3
ER -