Steroids for Deteriorating Herpes Simplex Virus Encephalitis

Banan Musallam; Israel Matoth; Dana G. Wolf; Dan Engelhard; Diana Averbuch

doi:10.1016/j.pediatrneurol.2007.05.007

Steroids for Deteriorating Herpes Simplex Virus Encephalitis

Banan Musallam
, Israel Matoth
, Dana G. Wolf
, Dan Engelhard
, Diana Averbuch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A 16-month-old girl presented with herpes simplex virus type 1 encephalitis with involvement of bilateral parietofrontal lobes, left thalamus and cerebellum. She was treated with intravenous acyclovir. As her condition deteriorated, high-dose methylprednisolone was administered, resulting in remarkable improvement. This case suggests considering a short course of high-dose steroid therapy in severe herpes simplex encephalitis when there is clinical and radiologic deterioration in spite of appropriate antiviral therapy and decreasing viral load in the cerebrospinal fluid.

Original language	English
Pages (from-to)	229-232
Number of pages	4
Journal	Pediatric Neurology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.pediatrneurol.2007.05.007
State	Published - Sep 2007
Externally published	Yes

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abstract = "A 16-month-old girl presented with herpes simplex virus type 1 encephalitis with involvement of bilateral parietofrontal lobes, left thalamus and cerebellum. She was treated with intravenous acyclovir. As her condition deteriorated, high-dose methylprednisolone was administered, resulting in remarkable improvement. This case suggests considering a short course of high-dose steroid therapy in severe herpes simplex encephalitis when there is clinical and radiologic deterioration in spite of appropriate antiviral therapy and decreasing viral load in the cerebrospinal fluid.",

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AU - Wolf, Dana G.

AU - Engelhard, Dan

AU - Averbuch, Diana

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AB - A 16-month-old girl presented with herpes simplex virus type 1 encephalitis with involvement of bilateral parietofrontal lobes, left thalamus and cerebellum. She was treated with intravenous acyclovir. As her condition deteriorated, high-dose methylprednisolone was administered, resulting in remarkable improvement. This case suggests considering a short course of high-dose steroid therapy in severe herpes simplex encephalitis when there is clinical and radiologic deterioration in spite of appropriate antiviral therapy and decreasing viral load in the cerebrospinal fluid.

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Steroids for Deteriorating Herpes Simplex Virus Encephalitis

Abstract

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