Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells

Narmen Azazmeh, Ittai Ben-Porath*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

1 Scopus citations


p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.

Original languageAmerican English
Article number1819752
JournalMolecular and Cellular Oncology
Issue number6
StatePublished - 1 Nov 2020

Bibliographical note

Funding Information:
This study was supported by grants from the Israel Science Foundation (1009/13, 2092/18) and from the DKFZ-MOST Fund (CA-161) (I.B.), and by a fellowship from the Israel Council for Higher Education (N.A.)

Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.


  • CDKN2A
  • P16
  • Wnt
  • aging
  • epidermis
  • senescence


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