Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells

Narmen Azazmeh, Ittai Ben-Porath*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.

Original languageAmerican English
Article number1819752
JournalMolecular and Cellular Oncology
Volume7
Issue number6
DOIs
StatePublished - 1 Nov 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

  • CDKN2A
  • P16
  • Wnt
  • aging
  • epidermis
  • senescence

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