Abstract
p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.
Original language | English |
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Article number | 1819752 |
Journal | Molecular and Cellular Oncology |
Volume | 7 |
Issue number | 6 |
DOIs |
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State | Published - 1 Nov 2020 |
Bibliographical note
Publisher Copyright:© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
Keywords
- CDKN2A
- P16
- Wnt
- aging
- epidermis
- senescence