p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.
Bibliographical noteFunding Information:
This study was supported by grants from the Israel Science Foundation (1009/13, 2092/18) and from the DKFZ-MOST Fund (CA-161) (I.B.), and by a fellowship from the Israel Council for Higher Education (N.A.)
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.