TY - JOUR
T1 - Stimulation of osteoclastic bone resorption in a model of glycerol-induced acute renal failure
T2 - Evidence for a parathyroid hormone-independent mechanism
AU - Gal-Moscovici, A.
AU - Scherzer, P.
AU - Rubinger, D.
AU - Weiss, R.
AU - Dranitzki-Elhalel, M.
AU - Popovtzer, M. M.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - This study was undertaken to evaluate the bone changes occurring in rats with acute renal failure (ARF). Acute renal failure was induced in rats 24 hours after dehydration by an intramuscular injection of glycerol. After induction of ARF, the rats were divided into two groups, one of which underwent parathyroidectomy (PTX). Rats with normal renal function, matched for age and weight, were used as controls and divided into two groups, one of them for PTX. At termination of the study blood and urine chemistry and bone histomorphometry were analyzed. Rats with glycerol-induced ARF developed bone changes compatible with mild hyperparathyroid bone disease, characterized mainly by increased osteoclastic bone resorption when compared with control rats having normal renal function. Rats with normal renal function following PTX developed bone disease showing complete suppression of forming and resorptive parameters. Rats with glycerol-induced ARF and PTX showed abolishment of all bone forming parameters, but a dramatic increase in osteoclastic resorption was apparent. Based on these observations we suggest that, in this model of glycerol-induced ARF, osteoclastic bone resorption may develop in the absence of parathyroid hormone, probably stimulated by other potent osteoclastogenic factors.
AB - This study was undertaken to evaluate the bone changes occurring in rats with acute renal failure (ARF). Acute renal failure was induced in rats 24 hours after dehydration by an intramuscular injection of glycerol. After induction of ARF, the rats were divided into two groups, one of which underwent parathyroidectomy (PTX). Rats with normal renal function, matched for age and weight, were used as controls and divided into two groups, one of them for PTX. At termination of the study blood and urine chemistry and bone histomorphometry were analyzed. Rats with glycerol-induced ARF developed bone changes compatible with mild hyperparathyroid bone disease, characterized mainly by increased osteoclastic bone resorption when compared with control rats having normal renal function. Rats with normal renal function following PTX developed bone disease showing complete suppression of forming and resorptive parameters. Rats with glycerol-induced ARF and PTX showed abolishment of all bone forming parameters, but a dramatic increase in osteoclastic resorption was apparent. Based on these observations we suggest that, in this model of glycerol-induced ARF, osteoclastic bone resorption may develop in the absence of parathyroid hormone, probably stimulated by other potent osteoclastogenic factors.
KW - Acute renal failure (ARF)
KW - Histomorphometry
KW - Osteoclastic bone resorption
KW - Parathyroidectomy (PTX)
KW - Rats
KW - Secondary hyperparathyroidism
UR - http://www.scopus.com/inward/record.url?scp=0036795980&partnerID=8YFLogxK
U2 - 10.1016/S8756-3282(02)00849-9
DO - 10.1016/S8756-3282(02)00849-9
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C2 - 12398944
AN - SCOPUS:0036795980
SN - 8756-3282
VL - 31
SP - 488
EP - 491
JO - Bone
JF - Bone
IS - 4
ER -