Stimulation of Prolactin Secretion by Perphenazine in Pituitary-Hypothalamus Organ Culture

A. Danon; S. Dikstein; F. G. Sulman

doi:10.3181/00379727-114-28679

Stimulation of Prolactin Secretion by Perphenazine in Pituitary-Hypothalamus Organ Culture

A. Danon, S. Dikstein, F. G. Sulman

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Pituitary explants on medium “199′”released an average of 0.05 IU prolactin daily. Pituitary-hypothalamus co-cultures released only an average of 0.025 IU/d. Other brain parts in co-culture failed to depress prolactin release, nor did hypothalami of perphenazine-primed rats or hypothalami to which perphenazine was added in vitro. The method described is a valuable tool for appraisal of prolactin releasing or inhibiting agents.

Original language	English
Pages (from-to)	366-368
Number of pages	3
Journal	Experimental Biology and Medicine
Volume	114
Issue number	2
DOIs	https://doi.org/10.3181/00379727-114-28679
State	Published - Nov 1963

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abstract = "Pituitary explants on medium “199′”released an average of 0.05 IU prolactin daily. Pituitary-hypothalamus co-cultures released only an average of 0.025 IU/d. Other brain parts in co-culture failed to depress prolactin release, nor did hypothalami of perphenazine-primed rats or hypothalami to which perphenazine was added in vitro. The method described is a valuable tool for appraisal of prolactin releasing or inhibiting agents.",

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Stimulation of Prolactin Secretion by Perphenazine in Pituitary-Hypothalamus Organ Culture

Abstract

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