TY - JOUR
T1 - Stimuli-Responsive DNA-Functionalized Nano-/Microcontainers for Switchable and Controlled Release
AU - Lu, Chun Hua
AU - Willner, Itamar
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Stimuli-responsive DNA-functionalized nano- and microcontainers composed of mesoporous SiO2 nanoparticles (MP SiO2 NPs), microcapsules, or micelles/vesicles act as carriers for the transport and release of drugs. The information encoded in the DNA sequences provides instructive information for the gating of drug-loaded pores of MP SiO2 NPs, for the assembly and degradation of microcapsules or lipid-DNA micelles/vesicles, and for the targeting of nano-/microcontainers to cancer cells. Different triggers are applied to release the drugs loaded in the nano-/microcontainers by unlocking the pores of the MP SiO2 NPs or by degradation of the containers. These include the use of switchable DNA nanostructures (nucleic acid hairpins, i-motif, G-quadruplexes) and the implementation of chemical, thermal, or photonic stimuli. Also, catalytic processes stimulated by DNAzymes or enzymes are used to release drugs from the nano-/microcontainers. DNA gates: Stimuli-responsive DNA-functionalized nano- and microcontainers composed of mesoporous SiO2 nanoparticles, microcapsules, or micelles/vesicles act as drug carriers for targeted controlled release. Different stimuli such as chemical, photonic, thermal, and biocatalytic triggers are used to release the loaded drugs.
AB - Stimuli-responsive DNA-functionalized nano- and microcontainers composed of mesoporous SiO2 nanoparticles (MP SiO2 NPs), microcapsules, or micelles/vesicles act as carriers for the transport and release of drugs. The information encoded in the DNA sequences provides instructive information for the gating of drug-loaded pores of MP SiO2 NPs, for the assembly and degradation of microcapsules or lipid-DNA micelles/vesicles, and for the targeting of nano-/microcontainers to cancer cells. Different triggers are applied to release the drugs loaded in the nano-/microcontainers by unlocking the pores of the MP SiO2 NPs or by degradation of the containers. These include the use of switchable DNA nanostructures (nucleic acid hairpins, i-motif, G-quadruplexes) and the implementation of chemical, thermal, or photonic stimuli. Also, catalytic processes stimulated by DNAzymes or enzymes are used to release drugs from the nano-/microcontainers. DNA gates: Stimuli-responsive DNA-functionalized nano- and microcontainers composed of mesoporous SiO2 nanoparticles, microcapsules, or micelles/vesicles act as drug carriers for targeted controlled release. Different stimuli such as chemical, photonic, thermal, and biocatalytic triggers are used to release the loaded drugs.
KW - lipid-DNA micelles
KW - mesoporous nanoparticles
KW - microcapsules
KW - nanomedicine
KW - vesicles
UR - http://www.scopus.com/inward/record.url?scp=84943201617&partnerID=8YFLogxK
U2 - 10.1002/anie.201503054
DO - 10.1002/anie.201503054
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 26296181
AN - SCOPUS:84943201617
SN - 1433-7851
VL - 54
SP - 12212
EP - 12235
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 42
ER -
