Abstract
Swimming-induced analgesia was studied in 4 strains of mice differing in central opiate receptor density: C57BL/6By (C57). BALB/cBy (BALB/c). CXBK and CXBH. The degree of 'swim analgesia' significantly differed among strains in the order CXBH > BALB/c = C57 > CXBK. This order positively correlates with known differences in opiate receptor density in these strains. Naloxone reversed the analgesic effect of swimming in CXBH, C57 and BALB/c, but was ineffective in opiate receptor-deficient CXBK mice. These results suggest that genetic differences in central opiate receptor density influence the analgesic response to stressful stimuli.
Original language | English |
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Pages (from-to) | 188-190 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 447 |
Issue number | 1 |
DOIs | |
State | Published - 26 Apr 1988 |
Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by NIH Grant NS-07628 and by a gift from the David H. Murdock Foundation for Advanced Brain Studies.
Keywords
- Genetic difference
- Hypothermia
- Naloxone
- Opiate receptor
- Stress-induced analgesia