Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration

Przemyslaw Marek*, Raz Yirmiya, John C. Liebeskind

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Swimming-induced analgesia was studied in 4 strains of mice differing in central opiate receptor density: C57BL/6By (C57). BALB/cBy (BALB/c). CXBK and CXBH. The degree of 'swim analgesia' significantly differed among strains in the order CXBH > BALB/c = C57 > CXBK. This order positively correlates with known differences in opiate receptor density in these strains. Naloxone reversed the analgesic effect of swimming in CXBH, C57 and BALB/c, but was ineffective in opiate receptor-deficient CXBK mice. These results suggest that genetic differences in central opiate receptor density influence the analgesic response to stressful stimuli.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalBrain Research
Volume447
Issue number1
DOIs
StatePublished - 26 Apr 1988
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by NIH Grant NS-07628 and by a gift from the David H. Murdock Foundation for Advanced Brain Studies.

Keywords

  • Genetic difference
  • Hypothermia
  • Naloxone
  • Opiate receptor
  • Stress-induced analgesia

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