Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration

Przemyslaw Marek; Raz Yirmiya; John C. Liebeskind

doi:10.1016/0006-8993(88)90984-5

Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration

Przemyslaw Marek^*
, Raz Yirmiya
, John C. Liebeskind

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Swimming-induced analgesia was studied in 4 strains of mice differing in central opiate receptor density: C57BL/6By (C57). BALB/cBy (BALB/c). CXBK and CXBH. The degree of 'swim analgesia' significantly differed among strains in the order CXBH > BALB/c = C57 > CXBK. This order positively correlates with known differences in opiate receptor density in these strains. Naloxone reversed the analgesic effect of swimming in CXBH, C57 and BALB/c, but was ineffective in opiate receptor-deficient CXBK mice. These results suggest that genetic differences in central opiate receptor density influence the analgesic response to stressful stimuli.

Original language	English
Pages (from-to)	188-190
Number of pages	3
Journal	Brain Research
Volume	447
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90984-5
State	Published - 26 Apr 1988
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by NIH Grant NS-07628 and by a gift from the David H. Murdock Foundation for Advanced Brain Studies.

Keywords

Genetic difference
Hypothermia
Naloxone
Opiate receptor
Stress-induced analgesia

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10.1016/0006-8993(88)90984-5

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title = "Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration",

abstract = "Swimming-induced analgesia was studied in 4 strains of mice differing in central opiate receptor density: C57BL/6By (C57). BALB/cBy (BALB/c). CXBK and CXBH. The degree of 'swim analgesia' significantly differed among strains in the order CXBH > BALB/c = C57 > CXBK. This order positively correlates with known differences in opiate receptor density in these strains. Naloxone reversed the analgesic effect of swimming in CXBH, C57 and BALB/c, but was ineffective in opiate receptor-deficient CXBK mice. These results suggest that genetic differences in central opiate receptor density influence the analgesic response to stressful stimuli.",

keywords = "Genetic difference, Hypothermia, Naloxone, Opiate receptor, Stress-induced analgesia",

author = "Przemyslaw Marek and Raz Yirmiya and Liebeskind, \{John C.\}",

note = "Funding Information: This study was supported by NIH Grant NS-07628 and by a gift from the David H. Murdock Foundation for Advanced Brain Studies.",

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doi = "10.1016/0006-8993(88)90984-5",

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AU - Marek, Przemyslaw

AU - Yirmiya, Raz

AU - Liebeskind, John C.

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AB - Swimming-induced analgesia was studied in 4 strains of mice differing in central opiate receptor density: C57BL/6By (C57). BALB/cBy (BALB/c). CXBK and CXBH. The degree of 'swim analgesia' significantly differed among strains in the order CXBH > BALB/c = C57 > CXBK. This order positively correlates with known differences in opiate receptor density in these strains. Naloxone reversed the analgesic effect of swimming in CXBH, C57 and BALB/c, but was ineffective in opiate receptor-deficient CXBK mice. These results suggest that genetic differences in central opiate receptor density influence the analgesic response to stressful stimuli.

KW - Genetic difference

KW - Hypothermia

KW - Naloxone

KW - Opiate receptor

KW - Stress-induced analgesia

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Strain differences in the magnitude of swimming-induced analgesia in mice correlate with brain opiate receptor concentration

Abstract

Bibliographical note

Keywords

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