Strategies for mapping and cloning quantitative trait genes in rodents

Jonathan Flint*, William Valdar, Sagiv Shifman, Richard Mott

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

431 Scopus citations


Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1% have been characterized at a molecular level. However, new resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin-Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable. We review the potential of these strategies to identify genes that underlie QTLs in rodents.

Original languageAmerican English
Pages (from-to)271-286
Number of pages16
JournalNature Reviews Genetics
Issue number4
StatePublished - Apr 2005
Externally publishedYes

Bibliographical note

Funding Information:
The authors are supported by the Wellcome Trust. We would like to thank C. Benoist for comments on the manuscript.


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