Strategies to assess structural variation in the chicken genome and its associations with biodiversity and biological performance

M. Soller, S. Weigend, M. N. Romanov, J. C.M. Dekkers, S. J. Lamont*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

A primary goal in the assessment of structural variation in the avian genome is to understand the relationship of this variation with biodiversity and with biological performance. To develop such knowledge, certain essential tools are needed. One set of tools includes the laboratory techniques used to assess molecular genetic variation. The current time is a transitional one for this field, in that the recently sequenced chicken genome will add significantly to the portfolio of existing methods used to identify molecular markers. To most efficiently discover marker-trait associations, the experimental mapping populations must be appropriately designed and the relevant statistical analyses applied. This paper reviews methods for assessment of molecular markers in poultry and their use in the characterization of avian biodiversity and in studies to identify marker associations with biological traits, including important considerations of population structure and statistical analysis.

Original languageEnglish
Pages (from-to)2061-2078
Number of pages18
JournalPoultry Science
Volume85
Issue number12
DOIs
StatePublished - Dec 2006

Keywords

  • Biodiversity
  • Candidate gene
  • Genome
  • Quantitative trait gene
  • Structural variation

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