Stress and pain responses in rats lacking CCK1 receptors

I. Hurwitz, O. Malkesman, Y. Stern, M. Schroeder, Y. Lavi-Avnon, M. Shayit, Y. Shavit, G. Wolf, R. Yirmiya, A. Weller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


CCK involvement in stress- and pain-responsiveness was examined by studying the behavior of infant (11-12-days-old) and adult OLETF rats that do not express CCK1 receptors. Infant odor- and texture-preferences were also assessed. We hypothesized that OLETF rats will show behavioral patterns similar to those previously observed after CCK1 antagonist administration. Rate of separation-induced ultrasonic vocalization was significantly greater in OLETF compared to controls, in two separate studies. Infant pups of the two strains did not differ in odor- and texture-preference tests. OLETF rats showed consistently longer hot-plate paw-lift (as infants, in two separate studies) and paw-lick (as adults) latencies. Summary: OLETF pups vocalized in isolation more than controls and showed relative hypoalgesic responses, evident also in adulthood, in concordance with the pharmacological literature.

Original languageAmerican English
Pages (from-to)1483-1489
Number of pages7
Issue number6
StatePublished - Jun 2006

Bibliographical note

Funding Information:
The rats were a generous gift of Dr. Kawano of Tokushima Research Institute and Otsuka Pharmaceutical, Tokushima, Japan. The authors thank Ofra Schwartz for animal care and careful maintenance of “blind” coding of the litters’ genotypes. The authors thank Adi David, Itay Peleg, Danielle Schwartz and Daniel Markovitz for help in data collection. OM and YLA were supported by the President's doctoral fellowship, Bar-Ilan University. OM was supported beforehand by a fellowship from Bar-Ilan University's Interdisciplinary Studies Committee. This work was supported by a grant from the Israel Science Foundation to AW.


  • Anxiety
  • CCK
  • Natural preference
  • OLETF rats
  • Pain
  • USV


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