Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

Felix Bergmann; Boris Yagen

doi:10.1007/BF00316439

Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

Felix Bergmann^*, Boris Yagen

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.

Original language	English
Pages (from-to)	155-156
Number of pages	2
Journal	Archives of Toxicology
Volume	63
Issue number	2
DOIs	https://doi.org/10.1007/BF00316439
State	Published - Apr 1989

Keywords

Intracerebral administration
Structure-toxicity relationships
Trichothecenes

Access to Document

10.1007/BF00316439

Cite this

@article{a8924bfb8436491da9c16498d3839c89,

title = "Structure-activity relationships for the direct toxic action of trichothecenes on rat brain",

abstract = "Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.",

keywords = "Intracerebral administration, Structure-toxicity relationships, Trichothecenes",

author = "Felix Bergmann and Boris Yagen",

year = "1989",

month = apr,

doi = "10.1007/BF00316439",

language = "אנגלית",

volume = "63",

pages = "155--156",

journal = "Archives of Toxicology",

issn = "0340-5761",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

AU - Bergmann, Felix

AU - Yagen, Boris

PY - 1989/4

Y1 - 1989/4

N2 - Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.

AB - Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.

KW - Intracerebral administration

KW - Structure-toxicity relationships

KW - Trichothecenes

UR - http://www.scopus.com/inward/record.url?scp=0024564352&partnerID=8YFLogxK

U2 - 10.1007/BF00316439

DO - 10.1007/BF00316439

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 2730341

AN - SCOPUS:0024564352

SN - 0340-5761

VL - 63

SP - 155

EP - 156

JO - Archives of Toxicology

JF - Archives of Toxicology

IS - 2

ER -

Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this