Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

Felix Bergmann; Boris Yagen

doi:10.1007/BF00316439

Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

Felix Bergmann^*, Boris Yagen

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.

Original language	English
Pages (from-to)	155-156
Number of pages	2
Journal	Archives of Toxicology
Volume	63
Issue number	2
DOIs	https://doi.org/10.1007/BF00316439
State	Published - Apr 1989

Keywords

Intracerebral administration
Structure-toxicity relationships
Trichothecenes

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10.1007/BF00316439

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abstract = "Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.",

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KW - Intracerebral administration

KW - Structure-toxicity relationships

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Structure-activity relationships for the direct toxic action of trichothecenes on rat brain

Abstract

Keywords

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