Structure-Activity Relationships of Pyrrole Amidine Antiviral Antibiotics. 2. Preparation of Mono-and Tripyrrole Derivatives of Congocidine

Meir Bialer; Boris Yagen; Raphael Mechoulam; Yechiel Becker

doi:10.1021/jm00184a018

Structure-Activity Relationships of Pyrrole Amidine Antiviral Antibiotics. 2. Preparation of Mono-and Tripyrrole Derivatives of Congocidine

Meir Bialer^*, Boris Yagen, Raphael Mechoulam, Yechiel Becker

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Representatives of three types of congocidine (1) analogues were synthesized. These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HSV DNA in isolated nuclei in vitro, as well as on DNA synthesis by purified HSV DNA polymerase. All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three antiviral tests.

Original language	English
Pages (from-to)	1144-1148
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	23
Issue number	10
DOIs	https://doi.org/10.1021/jm00184a018
State	Published - 1 Oct 1980

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/jm00184a018

Cite this

@article{7e90fdc8c7fc4ef59e882e41419e9c43,

title = "Structure-Activity Relationships of Pyrrole Amidine Antiviral Antibiotics. 2. Preparation of Mono-and Tripyrrole Derivatives of Congocidine",

abstract = "Representatives of three types of congocidine (1) analogues were synthesized. These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HSV DNA in isolated nuclei in vitro, as well as on DNA synthesis by purified HSV DNA polymerase. All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three antiviral tests.",

author = "Meir Bialer and Boris Yagen and Raphael Mechoulam and Yechiel Becker",

year = "1980",

month = oct,

day = "1",

doi = "10.1021/jm00184a018",

language = "אנגלית",

volume = "23",

pages = "1144--1148",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Structure-Activity Relationships of Pyrrole Amidine Antiviral Antibiotics. 2. Preparation of Mono-and Tripyrrole Derivatives of Congocidine

AU - Bialer, Meir

AU - Yagen, Boris

AU - Mechoulam, Raphael

AU - Becker, Yechiel

PY - 1980/10/1

Y1 - 1980/10/1

N2 - Representatives of three types of congocidine (1) analogues were synthesized. These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HSV DNA in isolated nuclei in vitro, as well as on DNA synthesis by purified HSV DNA polymerase. All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three antiviral tests.

AB - Representatives of three types of congocidine (1) analogues were synthesized. These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HSV DNA in isolated nuclei in vitro, as well as on DNA synthesis by purified HSV DNA polymerase. All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three antiviral tests.

UR - http://www.scopus.com/inward/record.url?scp=0019186958&partnerID=8YFLogxK

U2 - 10.1021/jm00184a018

DO - 10.1021/jm00184a018

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 6252323

AN - SCOPUS:0019186958

SN - 0022-2623

VL - 23

SP - 1144

EP - 1148

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 10

ER -

Structure-Activity Relationships of Pyrrole Amidine Antiviral Antibiotics. 2. Preparation of Mono-and Tripyrrole Derivatives of Congocidine

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this