Structure activity relationships of thiosemicarbazones on vaccinia virus and IBT-dependent mutant

Ehud Katz*, Eva Margalith, Bela Winer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Twenty-seven isatin β-thiosemicarbazone (IBT) related chemicals, among them benzaldehydes, triazinoindoles, pyrrolidine and acyclic compounds, were examined for their capability to inhibit the growth of vaccinia virus and to support the growth of the IBT-dependent mutant in BSCI cells. Eighteen compounds did not affect the growth of either one of the two virus strains. Nine compounds, which had an intact thiosemicarbazone side chain, attached to a certain cyclic structure, were able to inhibit the growth of the wt strain and to support the growth of the IBTD mutant. No compound was found to perform only one of these two functions.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume2
Issue number3
DOIs
StatePublished - Sep 1976

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