TY - JOUR
T1 - Structure activity relationships of thiosemicarbazones on vaccinia virus and IBT-dependent mutant
AU - Katz, Ehud
AU - Margalith, Eva
AU - Winer, Bela
PY - 1976/9
Y1 - 1976/9
N2 - Twenty-seven isatin β-thiosemicarbazone (IBT) related chemicals, among them benzaldehydes, triazinoindoles, pyrrolidine and acyclic compounds, were examined for their capability to inhibit the growth of vaccinia virus and to support the growth of the IBT-dependent mutant in BSCI cells. Eighteen compounds did not affect the growth of either one of the two virus strains. Nine compounds, which had an intact thiosemicarbazone side chain, attached to a certain cyclic structure, were able to inhibit the growth of the wt strain and to support the growth of the IBTD mutant. No compound was found to perform only one of these two functions.
AB - Twenty-seven isatin β-thiosemicarbazone (IBT) related chemicals, among them benzaldehydes, triazinoindoles, pyrrolidine and acyclic compounds, were examined for their capability to inhibit the growth of vaccinia virus and to support the growth of the IBT-dependent mutant in BSCI cells. Eighteen compounds did not affect the growth of either one of the two virus strains. Nine compounds, which had an intact thiosemicarbazone side chain, attached to a certain cyclic structure, were able to inhibit the growth of the wt strain and to support the growth of the IBTD mutant. No compound was found to perform only one of these two functions.
UR - http://www.scopus.com/inward/record.url?scp=0017181382&partnerID=8YFLogxK
U2 - 10.1093/jac/2.3.255
DO - 10.1093/jac/2.3.255
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C2 - 977525
AN - SCOPUS:0017181382
SN - 0305-7453
VL - 2
SP - 255
EP - 260
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 3
ER -