Structure and biological activity of heparinoid

Neeraj Kumar, A. Bentolila, A. J. Domb*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective anti-metastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalMini-Reviews in Medicinal Chemistry
Volume5
Issue number5
DOIs
StatePublished - May 2005

Keywords

  • Anticoagulant
  • FGF release
  • Heparan sulfate
  • Heparanase inhibitors
  • Heparin
  • Heparinoid
  • Poly(acryl amino acid)
  • Polyanion

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