Abstract
Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective anti-metastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
Original language | English |
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Pages (from-to) | 441-447 |
Number of pages | 7 |
Journal | Mini-Reviews in Medicinal Chemistry |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - May 2005 |
Keywords
- Anticoagulant
- FGF release
- Heparan sulfate
- Heparanase inhibitors
- Heparin
- Heparinoid
- Poly(acryl amino acid)
- Polyanion