TY - JOUR
T1 - Structure and function in red cell permeability
AU - Stein, W. D.
AU - Danielli, J. F.
PY - 1956
Y1 - 1956
N2 - It is postulated that facilitated diffusion through the cell plasma membrane takes place through a hydrogen-bonding stereochemically specific membrane component which extends through the thickness of the membrane. It was predicted that facilitated diffusion will be slowed by the presence of other hydrogen-bonding molecules, as a result of competition for hydrogen-bonding sites in the membrane component. This competitive inhibition is shown to be produced by ethylene glycol, propylene glycol, ethanol, butanol, urethane and phenol. Data are also presented for inhibition by copper, which acts as a non-competitive inhibitor.
AB - It is postulated that facilitated diffusion through the cell plasma membrane takes place through a hydrogen-bonding stereochemically specific membrane component which extends through the thickness of the membrane. It was predicted that facilitated diffusion will be slowed by the presence of other hydrogen-bonding molecules, as a result of competition for hydrogen-bonding sites in the membrane component. This competitive inhibition is shown to be produced by ethylene glycol, propylene glycol, ethanol, butanol, urethane and phenol. Data are also presented for inhibition by copper, which acts as a non-competitive inhibitor.
UR - http://www.scopus.com/inward/record.url?scp=0008356810&partnerID=8YFLogxK
U2 - 10.1039/DF9562100238
DO - 10.1039/DF9562100238
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AN - SCOPUS:0008356810
SN - 0366-9033
VL - 21
SP - 238
EP - 251
JO - Discussions of the Faraday Society
JF - Discussions of the Faraday Society
ER -