Abstract
Isomers of distamycin A and tripyrrole congocidine containing 2,5‐disubstituted pyrroles were synthesized along with distamycin and congocidine homologs containing a single pyrrole ring. Selected compounds were evaluated for their cytotoxicity and antiviral activity. All of the tripyrrole derivatives tested in this series were nontoxic but were less active than distamycin A. The monopyrrole derivative, N‐methyl‐5‐nitropyrrole‐2‐carboxamido‐β‐propionamidine hydrochloride, was nontoxic and was almost as active antivirally as distamycin A.
Original language | English |
---|---|
Pages (from-to) | 1334-1338 |
Number of pages | 5 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 69 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1980 |
Keywords
- Antibiotics—distamycin A and congocidine derivatives based on 2,5‐disubstituted pyrroles, synthesis and evaluation for cytotoxicity and antiviral activity, structure–activity relationships
- Congocidine—derivatives based on 2,5‐disubstituted pyrroles, synthesis and evaluation for cytotoxicity and antiviral activity, structure–activity relationships
- Distamycin—derivatives based on 2,5‐disubstituted pyrroles, synthesis and evaluation for cytotoxicity and antiviral activity, structure–activity relationships
- Structure–activity relationships—distamycin A and congocidine derivatives based on 2,5‐disubstituted pyrroles, antiviral activity