Abstract
The H-2 isoantigenicity of murine tissues was unaffected by the intraperitoneal growth of the Ehrlich ascites tumor, as shown by their normal capacity to absorb H-2 isohemagglutinins. Skin grafts from Ehrlich ascites tumor-bearing C57BL mice had a longer survival in RIII mice than grafts from normal donors. First-set allografts from tumor-bearing donors effectively immunized the hosts against second-set allografts from normal donors. Second-set allografts from tumor-bearing mice showed a prolonged survival in mice presensitized by first-set allografts from either normal or tumor-bearing donors. It therefore seems that the prolonged survival of skin allografts from tumor-bearing donors is not due to their decreased antigenicity or deficient immunogenicity, but rather to their increased resistance to the allograft reaction of the host.
Original language | English |
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Pages (from-to) | 462-464 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 28 |
Issue number | 3 |
State | Published - 1 Mar 1968 |
Externally published | Yes |