Studies on the Mechanism of Prolonged Survival of Allografts from Tumor-bearing Donors

E. Robinson, V. K. Golakai, M. Schlesinger

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The H-2 isoantigenicity of murine tissues was unaffected by the intraperitoneal growth of the Ehrlich ascites tumor, as shown by their normal capacity to absorb H-2 isohemagglutinins. Skin grafts from Ehrlich ascites tumor-bearing C57BL mice had a longer survival in RIII mice than grafts from normal donors. First-set allografts from tumor-bearing donors effectively immunized the hosts against second-set allografts from normal donors. Second-set allografts from tumor-bearing mice showed a prolonged survival in mice presensitized by first-set allografts from either normal or tumor-bearing donors. It therefore seems that the prolonged survival of skin allografts from tumor-bearing donors is not due to their decreased antigenicity or deficient immunogenicity, but rather to their increased resistance to the allograft reaction of the host.

Original languageEnglish
Pages (from-to)462-464
Number of pages3
JournalCancer Research
Volume28
Issue number3
StatePublished - 1 Mar 1968
Externally publishedYes

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