Abstract
By means of in vitro experiments, the mechanism of drug release from tablets prepared with scleroglucan, a polysaccharide that behaves as a gel-forming swellable matrix, was studied. Scleroglucan is not affected by environmental pH conditions and was found to be suitable for the formulation of slow release non-disintegrating oral dosage forms. Studies were performed with several model drugs under different environmental conditions. It was found that penetration of the solvent into the matrix is an important factor in determining the rate of drug delivery from this polymer.
| Original language | English |
|---|---|
| Pages (from-to) | 432-436 |
| Number of pages | 5 |
| Journal | Pharmazie |
| Volume | 48 |
| Issue number | 6 |
| State | Published - 1993 |