Study of normal and malignant white blood cells by time domain dielectric spectroscopy

Irina Ermolina*, Yulia Polevaya, Yuri Feldman, Ben Zion Ginzburg, Michael Schlesinger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

The aim of this paper is to present a comprehensive theoretical and experimental study by means of time domain dielectric spectrometer (TDDS) of static and dynamic dielectric properties of normal and malignant blood cells. The successful use of the TDDS method as a tool of human cell study required a special protocol and algorithms for all stages of cell preparation, measurements and data treatment. The routine developed in this study was used in the experimental analysis of nine lines of malignant, transformed and normal lymphocytes. It was shown that dielectric permittivity, capacitance and conductivity values of the cell membrane are higher for normal lymphocytes in comparison with malignant ones.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalIEEE Transactions on Dielectrics and Electrical Insulation
Volume8
Issue number2
DOIs
StatePublished - Apr 2001

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