TY - JOUR
T1 - Study of the DNA binding mechanism and in vitro activity against cancer cells of iron(iii) and aluminium(iii) kojic acid derivative complexes
AU - Lachowicz, Joanna I.
AU - Mateddu, Anna
AU - Coni, Pierpaolo
AU - Caltagirone, Claudia
AU - Murgia, Sergio
AU - Gibson, Dan
AU - dalla Torre, Gabriele
AU - Lopez, Xabier
AU - Meloni, Federico
AU - Pichiri, Giuseppina
N1 - Publisher Copyright:
© 2022 The Royal Society of Chemistry.
PY - 2022/4/4
Y1 - 2022/4/4
N2 - Metal ions have unique electrochemical and spectroscopical properties that cannot be attained by purely organic compounds. Most of the metal ions are toxic to humans, but paradoxically, metallodrugs are used in medicine as therapeutics and theranostics. Metallodrugs are eliminated in urine and faeces, and therefore release toxic metals and ligands into aquatic ecosystems, thereby raising concerns regarding environmental risks. The use of metallodrugs based on essential metal ions (i.e., iron, copper and zinc), instead of toxic ions, is a new alternative with minor hazards. Kojic acid is an Asperigillus oryzae metabolite of low toxicity used in the food and cosmetics industries. Its derivatives form stable complexes with iron(iii) ions, which bind effectively to DNA and inhibit DNA polymerization. The iron(iii)/S2 ligand complexes reduce in vitro colon carcinoma (Caco2) cell viability and significantly decrease the cell number. The kojic acid derivative complexes with iron(iii) presented here are an alternative to the currently used platinum complexes in cancer therapy.
AB - Metal ions have unique electrochemical and spectroscopical properties that cannot be attained by purely organic compounds. Most of the metal ions are toxic to humans, but paradoxically, metallodrugs are used in medicine as therapeutics and theranostics. Metallodrugs are eliminated in urine and faeces, and therefore release toxic metals and ligands into aquatic ecosystems, thereby raising concerns regarding environmental risks. The use of metallodrugs based on essential metal ions (i.e., iron, copper and zinc), instead of toxic ions, is a new alternative with minor hazards. Kojic acid is an Asperigillus oryzae metabolite of low toxicity used in the food and cosmetics industries. Its derivatives form stable complexes with iron(iii) ions, which bind effectively to DNA and inhibit DNA polymerization. The iron(iii)/S2 ligand complexes reduce in vitro colon carcinoma (Caco2) cell viability and significantly decrease the cell number. The kojic acid derivative complexes with iron(iii) presented here are an alternative to the currently used platinum complexes in cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85128800025&partnerID=8YFLogxK
U2 - 10.1039/d2dt00111j
DO - 10.1039/d2dt00111j
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 35373808
AN - SCOPUS:85128800025
SN - 1477-9226
VL - 51
SP - 6254
EP - 6263
JO - Dalton Transactions
JF - Dalton Transactions
IS - 16
ER -