TY - JOUR
T1 - Subcellular particles for characterization of host-parasite interactions
AU - Kozela, Ewa
AU - Meneghetti, Paula
AU - Regev-Rudzki, Neta
AU - Torrecilhas, Ana Claudia
AU - Porat, Ziv
N1 - Publisher Copyright:
© 2024 Institut Pasteur
PY - 2024/9/1
Y1 - 2024/9/1
N2 - Parasitic diseases remain a major global health problem for humans. Parasites employ a variety of strategies to invade and survive within their hosts and to manipulate host defense mechanisms, always in the pathogen's favor. Extracellular vesicles (EVs), membrane-bound nanospheres carrying a variety of bioactive compounds, were shown to be released by the parasites during all stages of the infection, enabling growth and expansion within the host and adaptation to frequently changing environmental stressors. In this review, we discuss how the use of existing nanotechnologies and high-resolution imaging tools assisted in revealing the role of EVs during parasitic infections, enabling the quantitation, visualization, and detailed characterization of EVs. We discuss here the cases of malaria, Chagas disease and leishmaniasis as examples of parasitic neglected tropical diseases (NTDs). Unraveling the EVs' role in the NTD pathogenesis may enormously contribute to their early and reliable diagnostic, effective treatment, and prevention.
AB - Parasitic diseases remain a major global health problem for humans. Parasites employ a variety of strategies to invade and survive within their hosts and to manipulate host defense mechanisms, always in the pathogen's favor. Extracellular vesicles (EVs), membrane-bound nanospheres carrying a variety of bioactive compounds, were shown to be released by the parasites during all stages of the infection, enabling growth and expansion within the host and adaptation to frequently changing environmental stressors. In this review, we discuss how the use of existing nanotechnologies and high-resolution imaging tools assisted in revealing the role of EVs during parasitic infections, enabling the quantitation, visualization, and detailed characterization of EVs. We discuss here the cases of malaria, Chagas disease and leishmaniasis as examples of parasitic neglected tropical diseases (NTDs). Unraveling the EVs' role in the NTD pathogenesis may enormously contribute to their early and reliable diagnostic, effective treatment, and prevention.
KW - Extracellular vesicles
KW - Flow cytometry
KW - Imaging flow cytometry
KW - Neglected Tropical diseases
KW - Parasites
KW - Plasmodium falciparum
UR - http://www.scopus.com/inward/record.url?scp=85186364192&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2024.105314
DO - 10.1016/j.micinf.2024.105314
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C2 - 38367661
AN - SCOPUS:85186364192
SN - 1286-4579
VL - 26
JO - Microbes and Infection
JF - Microbes and Infection
IS - 7
M1 - 105314
ER -
