Subcellular particles for characterization of host-parasite interactions

Ewa Kozela, Paula Meneghetti, Neta Regev-Rudzki, Ana Claudia Torrecilhas*, Ziv Porat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Parasitic diseases remain a major global health problem for humans. Parasites employ a variety of strategies to invade and survive within their hosts and to manipulate host defense mechanisms, always in the pathogen's favor. Extracellular vesicles (EVs), membrane-bound nanospheres carrying a variety of bioactive compounds, were shown to be released by the parasites during all stages of the infection, enabling growth and expansion within the host and adaptation to frequently changing environmental stressors. In this review, we discuss how the use of existing nanotechnologies and high-resolution imaging tools assisted in revealing the role of EVs during parasitic infections, enabling the quantitation, visualization, and detailed characterization of EVs. We discuss here the cases of malaria, Chagas disease and leishmaniasis as examples of parasitic neglected tropical diseases (NTDs). Unraveling the EVs' role in the NTD pathogenesis may enormously contribute to their early and reliable diagnostic, effective treatment, and prevention.

Original languageAmerican English
Article number105314
JournalMicrobes and Infection
DOIs
StateAccepted/In press - 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 Institut Pasteur

Keywords

  • Extracellular vesicles
  • Flow cytometry
  • Imaging flow cytometry
  • Neglected Tropical diseases
  • Parasites
  • Plasmodium falciparum

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