TY - JOUR
T1 - Substance P-induced cutaneous plasma extravasation in rats is mediated by NK-1 tachykinin receptors
AU - Devor, Marshall
AU - Papir-Kricheli, Dalia
AU - Nachmias, Eyal
AU - Rosenthal, Fernando
AU - Gilon, Chaim
AU - Chorev, Michael
AU - Selinger, Zvi
PY - 1989/8/28
Y1 - 1989/8/28
N2 - Substance P (SP), a relatively non-selective tachykinin receptor agonist, and Septide and Senktide, highly selective NK-1 and NK-3 tachykinin receptor agonists, respectively, were injected intradermally in rats. The resulting cutaneous plasma extravasation (PE) was evaluated by measuring the amount of Evans blue that leached from the circulation into the skin. SP and Septide produced dose dependent PE. Septide being the more potent of the two. Senktide did not produce PE, even at doses 10,000 times higher. Neonatal capsaicin treatment significantly reduced SP- and Septide-induced PE. These data indicate that SP-induced PE is mediated by NK-1 tachykinin receptors.
AB - Substance P (SP), a relatively non-selective tachykinin receptor agonist, and Septide and Senktide, highly selective NK-1 and NK-3 tachykinin receptor agonists, respectively, were injected intradermally in rats. The resulting cutaneous plasma extravasation (PE) was evaluated by measuring the amount of Evans blue that leached from the circulation into the skin. SP and Septide produced dose dependent PE. Septide being the more potent of the two. Senktide did not produce PE, even at doses 10,000 times higher. Neonatal capsaicin treatment significantly reduced SP- and Septide-induced PE. These data indicate that SP-induced PE is mediated by NK-1 tachykinin receptors.
KW - Neurogenic inflammation
KW - Plasma extravasation
KW - Senktide
KW - Septide
KW - Substance P
KW - Tachykinin
KW - Tachykinin receptor
UR - http://www.scopus.com/inward/record.url?scp=0024412034&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(89)90576-4
DO - 10.1016/0304-3940(89)90576-4
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C2 - 2475833
AN - SCOPUS:0024412034
SN - 0304-3940
VL - 103
SP - 203
EP - 208
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -