Substance P-induced cutaneous plasma extravasation in rats is mediated by NK-1 tachykinin receptors

Marshall Devor*, Dalia Papir-Kricheli, Eyal Nachmias, Fernando Rosenthal, Chaim Gilon, Michael Chorev, Zvi Selinger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Substance P (SP), a relatively non-selective tachykinin receptor agonist, and Septide and Senktide, highly selective NK-1 and NK-3 tachykinin receptor agonists, respectively, were injected intradermally in rats. The resulting cutaneous plasma extravasation (PE) was evaluated by measuring the amount of Evans blue that leached from the circulation into the skin. SP and Septide produced dose dependent PE. Septide being the more potent of the two. Senktide did not produce PE, even at doses 10,000 times higher. Neonatal capsaicin treatment significantly reduced SP- and Septide-induced PE. These data indicate that SP-induced PE is mediated by NK-1 tachykinin receptors.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalNeuroscience Letters
Volume103
Issue number2
DOIs
StatePublished - 28 Aug 1989

Keywords

  • Neurogenic inflammation
  • Plasma extravasation
  • Senktide
  • Septide
  • Substance P
  • Tachykinin
  • Tachykinin receptor

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