Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Orit Weil-Ktorza; Nischay Rege; Shifra Lansky; Deborah E. Shalev; Gil Shoham; Michael A. Weiss; Norman Metanis

doi:10.1002/chem.201901974

Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Orit Weil-Ktorza, Nischay Rege, Shifra Lansky, Deborah E. Shalev, Gil Shoham, Michael A. Weiss^*, Norman Metanis^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

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Abstract

Invited for the cover of this issue are the groups of Norman Metanis at The Hebrew University of Jerusalem and Michael A. Weiss at the Indiana University School of Medicine. The image depicts a simple method for the preparation of new insulin analogues with a particular interest in more stable analogues with extended shelf life. Read the full text of the article at 10.1002/chem.201900892.

Original language	English
Pages (from-to)	8430
Number of pages	1
Journal	Chemistry - A European Journal
Volume	25
Issue number	36
DOIs	https://doi.org/10.1002/chem.201901974
State	Published - 26 Jun 2019

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© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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AU - Shoham, Gil

AU - Weiss, Michael A.

AU - Metanis, Norman

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Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Abstract

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